The Medicines and Healthcare Products Regulatory Agency (MHRA) has approved tarlatamab (Imdylltra) as a treatment for adult patients with small cell lung cancer (SCLC) that has progressed to the lungs and/or other regions of the body. This approval came as part of Project Orbis, an innovative project that enables participating agencies to promptly and efficiently assess and approve applications for promising cancer treatments. SCLC is one of the two most common types of primary lung cancer, accounting for approximately one in every seven lung cancers. It is less prevalent than non-small-cell lung cancer and spreads faster.
Tarlatamab belongs to a group of medicines called antineoplastic agents, which kill cancer cells that rapidly divide. Tarlatamab can only be prescribed to patients that have previously been treated with two other types of treatments and if those treatments did not work or are no longer working. It’s is intended to be given through a vein (intravenously) as an infusion on three occasions in the first 3 weeks and then it is expected to be every 2 weeks thereafter.
The efficacy of Tarlatamab was primarily demonstrated in patients enrolled in a phase 2, open label multicentre trial, where tarlatamab was studied in patients with extensive-stage SCLC which had progressed or recurred following two previous lines of chemotherapy (with or without a checkpoint inhibitor). An overall response rate of 40% was seen, and the median duration of response was 9.7 months. Overall, these results are encouraging in patients with advanced SCLC who have limited treatment options and for whom there is a high unmet need for effective treatment options.
As with any medicine, the MHRA will keep the safety and effectiveness of tarlatamab under close review. Anyone who suspects they are having a side effect from this medicine are encouraged to talk to their doctor, pharmacist or nurse and report it directly to the MHRA Yellow Card scheme, either through the website (https://yellowcard.mhra.gov.uk/) or by searching the Google Play or Apple App stores for MHRA Yellow Card.
Learn more: Tarlatamab approved to treat adult patients with small cell lung cancer - GOV.UK