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First Ever Allergic Shock Treatment in Nasal Spray Form

August 27, 2025

The Medicines and Healthcare Products Regulatory Agency (MHRA) granted approval for EURneffy, the first intranasal adrenaline (epinephrine) treatment for emergency management of anaphylaxis, offering a needle-free alternative to traditional injectable options.

Anaphylactic shock is considered a very serious case that requires immediate response, as it leads to a sudden drop in blood pressure, which in turn makes it difficult to breathe, putting the patient in a life-threatening position.

Adrenaline has been established for a long period now as a life-saving treatment to counteract the effect of allergic reactions. However, this new dosage form is intended for the use of adults & children weighing 30 kg or above.

Julian Beach, MHRA Interim Executive Director of Healthcare Quality and Access, highlighted that patient safety is their top priority & they further encourage individuals at risk of severe allergic reactions, as well as those around them, to become well-informed on the appropriate steps to take in the event of an emergency. Guidance and resources are available on the MHRA website to support individuals in being well-prepared.

Moreover, it is advised to carry 2 nasal sprays, & the plunger should be pressed only after the insertion of the product into the nostril in case of requiring a second dose & preventing product loss, respectively.

Finally, anyone who suspects they may be experiencing a side effect from this medicine should seek advice from their doctor, pharmacist, or nurse and report it directly through the MHRA Yellow Card scheme.

Learn more: MHRA approves adrenaline nasal spray - the first needle-free emergency treatment for anaphylaxis in the UK - GOV.UK

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